A once-daily GLP-1 tablet — no injections required. Online consultations available nationwide, with delivery across Japan.
International patients are very welcome. Customs certificates for returning travelers are also available.
- We use semaglutide daily in our diabetes practice, giving us thorough knowledge of its properties and side effect management
- Comprehensive management of gastrointestinal symptoms (nausea, diarrhea). As internists, we can prescribe anti-nausea medication and additional treatments
- 血糖、血压、血脂等生活习惯病指标一并管理
- For those who were hesitant to start due to fear of injections, Rybelsus is the perfect first step
- If results are insufficient, we can discuss stepping up to an injectable (Mounjaro or Wegovy)
What Is Rybelsus?
Rybelsus (generic name: oral semaglutide) is the world’s first oral GLP-1 receptor agonist. It uses the same active ingredient as injectable Ozempic and Wegovy (semaglutide), made available in tablet form through a special absorption enhancer (SNAC). It is a genuinely innovative medication.
Taken just once a day in the morning on an empty stomach. Particularly suitable for those who are reluctant to start injections or who are beginning GLP-1 therapy for the first time.
Three Key Features of Rybelsus
适合哪些人？
- Those who dislike injections and want to start GLP-1 treatment with a tablet
- Those aiming for moderate weight loss of around 5 kg
- Those with diabetes or pre-diabetes who want to manage both blood sugar and body weight simultaneously
- Those who have an established daily medication routine
- Those who want to try GLP-1 therapy as an introduction before considering injectables
哪些人不能使用？
- Those with a history of pancreatitis
- Those with a personal or family history of medullary thyroid carcinoma or MEN2
- Those with severe gastrointestinal disorders (e.g. gastroparesis)
- 正在怀孕、计划怀孕或哺乳的人
- BMI低于18.5的人
常见副作用
Gastrointestinal symptoms are the most common. Most resolve within 2–4 weeks after starting. We can prescribe anti-nausea medication if needed.
| 副作用 | 频率 | 处理方法 |
|---|---|---|
| 恶心 | ~15% | 少量多次进食；止吐药 |
| 腹泻 | ~11% | 补充水分；整肠药 |
| 便秘 | ~9% | 补充水分、膳食纤维、泻药 |
| Decreased appetite | ~10–15% | 观察 (also a therapeutic effect) |
| Headache / dizziness | ~5–10% | 观察 |
| 急性胰腺炎（罕见） | <0.1% | 出现严重上腹/背部疼痛时立即就医 |
Important Instructions for Taking Rybelsus
How you take Rybelsus directly affects its effectiveness. Please follow these instructions carefully:
- Take immediately upon waking, on an empty stomach (at least 30 minutes before eating)
- Use no more than approx. 120 mL of water (about half a glass) to swallow the tablet
- Avoid food, drink, and other medications for 30 minutes after taking
- Swallow the tablet whole — do not crush or chew
费用（含税，运费另计）
运费：¥35,000以上免费 / ¥35,000以下¥1,500 / 不可退货 / 付款：信用卡、银行转账或现金
※ The first 4 weeks start at 3mg. 100 tablets = approx. 3–4 months (3mg) / approx. 1.5 months (7mg) / approx. 1 month (14mg)
就诊流程
💊 问诊费用
¥0 — 您已明确所需药物及剂量
¥5,500 — 您希望就药物选择、剂量或减重方案进行咨询 （日语或英语）
🏥 来院就诊（北海道札幌市中央区）
🖥 线上问诊（全国对应）
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预约
点击此处进行预约。
完成后，我们将通过电子邮件发送诊疗用URL。
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线上诊疗
无需安装任何应用程序！点击邮件中的URL即可。
将通过视频通话进行本人确认。（※ 依据日本厚生劳动省远程医疗指南）
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付款
仅限信用卡 -
配送
线上诊疗结束后进行结算，发货至您指定的地址。
可发往住宅、公司或酒店等全国各地。不支持海外发货。
※ 可为归国旅客开具海关证明。※ 不支持国际配送。
常见问题
- Q. 接受健康保险吗？
- 在没有糖尿病诊断的情况下用于减重时，治疗为自费（私人）。 已诊断为糖尿病的患者可能有资格享受保险覆盖。
- Q. How much weight can I expect to lose?
- Clinical trials show an average of 3–4 kg (approximately 4–5% of body weight) reduction when taking 14mg for 6 months to 1 year. Most patients notice results at 7mg or above.
- Q. How does Rybelsus compare to injectable GLP-1 medications?
- Even though both use semaglutide, the injectable (Wegovy) achieves greater weight loss (avg. ~15%). Rybelsus delivers approximately 4–5%, but offers the significant advantage of no injections. For those seeking stronger results, we can discuss stepping up to Wegovy or Mounjaro.
- Q. Why must Rybelsus be taken on an empty stomach?
- Taking it with food significantly reduces absorption and effectiveness. Taking it on an empty stomach with a small amount of water (approx. 120 mL), then waiting 30–60 minutes before eating, maximizes the drug’s efficacy.
- Q. 外国患者可以接受治疗吗？
- 是的，可提供英语服务。我们还可以在您返回本国时为您出具海关申报所需的诊断证明书。
- Q. 利贝苏斯（口服司美格鲁肽）有哪些副作用？
- 常见副作用包括：恶心、腹泻、呕吐、腹痛、便秘、食欲减退、头晕、急性胰腺炎、肠梗阻、胆道疾病、低血糖、急性肾损伤等。
- Q. 在线诊疗后，药品何时送达？
- 付款在线上诊疗期间完成。药品将于发货日后第二天送达（全国配送，北海道至冲绳）。
发货日因就诊时间而异。
以下情况可能导致延迟：就诊时间 发货日 周一・周二・周四・周五 11:30前 当天发货 其他（11:30后・周三・周六・休诊日） 次诊疗日发货
・批发商库存不足时
・台风・暴雪等恶劣天气导致的配送延误
预约线上或来院诊疗
预约 / 申请[Physician Explanation] Rybelsus (Oral Semaglutide): Effects, 副作用s, and PIONEER Trial Data